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Background: Pseudophakic
cystoid macular edema (CME) also known as Irvine-Gass syndrome, is one of the most
common causes of visual loss after cataract surgery. Pathogenesis is thought to
involve the release of inflammatory mediators and non-steroidal anti-inflammatory medications are
often used for CME prophylaxis. The aim of the study
is
to
determine
the
role
of
Nepafenac
0.1%
usage
in
altering
the
status
of
CME
as determined by OCT who underwent Cataract
Surgery.
Materials and
methods: A total of 100 subjects with a 1:1
control: Treatment ratio that underwent small incision cataract surgery (SICS),
Subjects were randomised in to 50 control group (standard of care only) and 50
treatment group (Standard of care plus nepafenac). Immediate post operatively, OCT scans were
carried out on 1st post-operative
day
and
at
4
weeks,
using
the
macular
thickness
protocol
with
the
stratus
OCT
version 5.0.1 at Santhiram General Hospital, Nandyal, between 2012-20 15.
Results: In
present study, the results demonstrated that with usage of postoperative
topical nepafenac 0.1% there were differences between the treatment group and
control
group regarding the OCT measured macular thickness. After analysing the data
and applying appropriate
statistical analysis it can be concluded that 0.1% Nepafenac can
be
used as a treatment option for primary CME in post cataract patients. Topical
therapy of 0.1% Nepafenac
related
side
effects
like
Keratitis,
corneal
melt and corneal
perforation
are
very rare and were not encountered in any patient in our
study.
Conclusion: In our study, results concluding that the topical
nepafenac 0.1% therapy has promising results for prevention of pseudophakic
cystoid macular edema.
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